Apport de l'immunohistochimie dans le diagnostic des lymphomes B agressifs chez les patients infectes ou non par le VIH en Republique democratique du Congo

Objectif. Determiner la contribution potentielle des techniques immunohistochimiques au diagnostic; et dans la prise en charge therapeutique des lymphomes-B agressifs chez des patients infectes ou non par le VIH; en R D Congo; dans le but de vulgarisation de cette approche; complementaire a l'etude morphologique; et indispensable pour le sous-typage de lymphomes; en particulier; de lymphomes-B agressifs. Methodes. Etude transversale et retrospective de 101 blocs de paraffine portant le diagnostic de lymphome et analyses entre 2005 et 2010; par des techniques morphologiques et immunohistochimiques; dans six laboratoires specialises de notre pays. Resultats. Les 81 blocs retenus; etaient tous CD20 positifs et CD3 negatifs; mais le profil etait variable pour d'autres marqueurs etudies. Le lymphome de Burkitt a ete identifie sur 40 blocs; incluant 7 sujets VIH+ (17;5); les lymphomes B diffus a grandes cellules; sur 35; avec 11; chez les VIH+ (31;4).Six lymphomes de forme intermediaire; dont 3; chez des sujets VIH+ (50). Conclusion. Cette etude a permis de classifier les lymphomes-B agressifs dans notre contexte; grace a l'immunohistochimie; justifiant le recours aux anticorps anti-CD20 pour leur traitement

Unusual appearance of a cerebral hydatid cyst as a hemorrhagic infarct

We herein present a 32-year-old Lebanese woman with a history of cardiac hydatid cyst presenting with headache, confusion, and right arm clumsiness. A CT of the head showed hemorrhagic infarct of the left fronto-parietal lobe. Eleven months later, the subsequent development of hydatid cysts within the necrotic area of the infracted hemisphere suggested a cerebral hydatid embolism of cardiac origin. In patients with a positive history of hydatid disease, hydatid embolism should be considered in the differential diagnosis of stroke in young patients

Associating urinary tract anomalies in ano-rectal malformations

Detailed study of the urinary tract had been done in our last twenty consecutive children born with anorectal malformations [A.R.M.] of both sexes. Associated urologic anomalies other than those anomalies which are part of the syndrome [e.g. rectourinary fistula] were found in sixteen out of the twenty children. This high incidence of associated urinary tract anomalies in patients with A.R.M. reflects the importance of a thorough urologic study irrespective of the sex or the type of the anorectal anomaly

Evaluation of computed tomography and hormonal profile in empty sella syndrome

Hormonal assay was done in 20 patients diagnosed as having empty sella syndrome using CT scan. 10 patients had the galactorrhea amenorrhea syndrome. There was significant increase in prolactin level and non significant decrease in gonadotrophic hormones. Both thyroid and adrenal hormones were normal. The role of CT scan as an important tool for diagnosis was reassessed and evaluated

Surgical reconstruction in benign strictures of bile duct

Reconstructive biliary surgery is mandatory in obstructive jaundice due to benign causes. Twenty five patients operated upon due to stricture in the common bile duct and/or common hepatic duct after cholycystectomy operation during the period from 1982-1988. Operations performed were choledchoduodenostomy for stricture of the common bile duct and hepaticojejunostomy using a Roux-en- Y loop of the jejunum for stricture of the common hepatic duct. The results were good with minimal complications and one mortality. In severely ill patients, percutaneous transhepatic biliary drainage improved the condition preoperatively

Haloperidol decanoato en reemplazo de combinaciones de antipsicoticos en el tratamiento de esquizofrenicos cronicos. / Haloperidol decanoate in replacement of antipsychotic agents combinations in the treatment of chronic schizophrenic patients

Veintidos pacientes esquizofrenicos cronicos parcial o totalmente refractarios a mas de un neuroleptico prescripto en diversas combinaciones, fueron tratados durante seis meses con haloperidol decanoato como terapeutica de reemplazo de las combinaciones de drogas antipsicoticas.Previo al inicio del tratamiento con haloperidol decanoato, se descontinuaron todos los neurolepticos durante una semana. Se estudio una posible diferencia en la eficacia terapeutica, los efectos colaterales, tanto extrapiramidales como otros, entre los diferentes tratamientos con neurolepticos en combinacion y haloperidol decanoato.Tambien se intento interrumpir la medicacion anti-parkinsoniana durante el curso del estudio. Se evaluo la eficacia clinica de haloperidol decanoato utilizanto la escala B.P.R.S. (escala de evaluacion psiquiatrica breve). El estudio demostro una significativa mejoria en muchos items y factores de dicha escala. Hubo menos efectos colaterales y diecisiete pacientes que recebian medicacion antiparkinsoniana pudieron suspender la misma mientras recibian haloperidol decanoato. La droga fue bien tolerada. Estos resultados indican que el administrar a los pacientes psicoticos mas de un neuroleptico carece de valor. Con una dosis ajustada individualmente, el haloperidol decanoato proporciona una efectiva monoterapia y hae el regimen terapeutico mas aceptable para los pacientes